Came across this little gem this morning.   Made a significant difference on my PC.
Here’s the best one. Add this to your web.config for MUCH faster compilation.
Quick summary: we are introducing a new optimizeCompilations switch in ASP.NET that can greatly improve the compilation speed in some scenarios. There are some catches, so read on for more details. This switch is currently available as a QFE for 3.5SP1, and will be part of VS 2010.
The ASP.NET compilation system takes a very conservative approach which causes it to wipe out any previous work that it has done any time a ‘top level’ file changes. ‘Top level’ files include anything in bin and App_Code, as well as global.asax. While this works fine for small apps, it becomes nearly unusable for very large apps. E.g. a customer was running into a case where it was taking 10 minutes to refresh a page after making any change to a ‘bin’ assembly.
To ease the pain, we added an ‘optimized’ compilation mode which takes a much less conservative approach to recompilation.